Recordings from the 2025 German Ophthalmological Society Congress. The symposium highlights current scientific and clinical aspects of the vitreous: from new treatment options for vitreous opacities aimed at improving quality of life, to the impact on the efficacy of intravitreal medication, modern replacement techniques, and the latest scientific insights into the role of hyalocytes. The goal is to deepen the understanding of the vitreous, provide insight into current research and preclinical work, and offer new impulses for diagnostics and therapy in direct patient care.