VitroCap®N: FAQ for Eye Care Professionals

VitroCap N package and capsules of the study testet micronutrient combination

Facts and Questions

Mechanism of Action

The vitreous body has a unique protective mechanism against oxidative stress and collagen glycation. However, this mechanism loses efficacy during degeneration. Providing the eye with naturally occurring micronutrients can help reactivate this mechanism, minimising or even preventing collagen fibres from clumping. The healthy vitreous exhibits notably high concentrations of micronutrients, including:

  • Vitamin C helps counter intraocular oxidative stress by consuming reactive oxygen species and free radicals in an ascorbate-dependent manner.
  • Zinc stimulates the synthesis of metallothionein, a metal-binding protein that protects tissues from glycoxidation, thus exhibiting antioxidative and antiglycation properties. Zinc is also an important cofactor of superoxide dismutase 3 (SOD3), a metalloprotein enzyme that catalyses the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Therefore, zinc also functions to regulate oxidative stress in the vitreous.
  • L-lysine, an essential free amino acid, helps prevent collagen glycation and serves as a chemical chaperone.

Other micronutrients are known to effectively combat oxidative stress and protein glycation:

  • Proanthocyanidins found in grapes have been shown to inhibit protein glycation.
  • Hesperidin regulates oxidative stress and reduces the level of inflammatory cytokines by inhibiting the formation of advanced glycation end products, which in turn reduces the glycation of collagen.

Incorporating these micronutrients through supplementation with VitroCap®N may potentially slow down or even reverse, the progression of floaters. The effectiveness of this approach has been demonstrated in five clinical trials.

Did you know that eye care professionals can request free samples of VitroCap®N here?

How to Objectively Prove the Reduction of Eye Floaters

In the Floater Intervention Study (FLIES), researchers used the ultra-widefield imaging module of the SPECTRALIS HRA + OCT from Heidelberg Engineering GmbH to capture a 30-second, 102° field, cross-polarised infrared reflectance video of the vitreous. Patients were asked to move their gaze in various directions, returning to a central fixation point after each movement. From the video, five still images of eye floaters were extracted, each from a different angle.

The vitreous opacity outlines were manually delineated using a ‘freehand selection‘ tool, and the areas of opacity were calculated for each image. These individual areas were then combined to provide a total measurement, reported in square centimetres.

Did you know?

The FLIES study is the first randomised, double-blind, placebo-controlled clinical trial to assess the impact of targeted nutritional supplementation on vitreous floaters. The trial included 61 patients aged 18-79 years. After 6 months of supplementation with VitroCap®N, 77% of patients experienced a reduction in vitreous opacity areas.

Expert Opinions and Clinical Feedback

VitroCap®N has been on the market for over 10 years, with eye care professionals across Europe gathering valuable clinical experience. These experts have shared their insights, contributing to a broader understanding of the supplement’s impact. In discussions and contributions from both internationally and nationally renowned physicians and researchers, the latest findings on vitreous degeneration were explored, including its effects on visual function and quality of life.

Optometry Today Roundtable: "Can your patients benefit from vitreous management?"

See the full discussion on YouTube.

  • Dr. Frank Eperjesi
  • Dr. Scott Mackie
  • Dr. Thomas Kaercher
  • Prof. John M. Nolan 

Satellite symposium: “Look at vitreous- not just through it.”

The videos from the symposium can be found here. 

  • Dr. Jerry Sebag
  • Prof. John M. Nolan
  • Prof. Hans Hoerauf
  • Dr. Thomas Kaercher
  • Prof. Ulrich Welge-Lüßen

Complete Study Data on VitroCap®N

Research Team
Year
Duration
Design
Success Rate
Link
Ankahmah et al
2021
6 months
RCT (double-blind)
66.7%
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525826/
Varganova et al.
2019
3 months
Case-control study
76%
https://journals.eco-vector.com/ov/article/view/11875
Sobol et al.
2018
3 months
Observational study
64.7%
https://www.researchgate.net/publication/326345092
Marchencko et al.
2015
3 months
Case-control study
65.5%
https://ebiga-vision.com/marchencko-et-al.pdf
Kaercher et al.
2013
3 months
Observational study
87.5%
https://ebiga-vision.com/ZPA_9-2023-eye-floater-symposium

Request free samples and informational material

ebiga-VISION aims to give medical professionals the opportunity to assess the product, provide their patients with comprehensive and straightforward advice, and offer them an evidence-based option for the management of floaters.

How to Stock VitroCap®N for Resale

Please contact us using our contact form. We would be happy to send you a PDF with our current prices and discount levels for practice shop owners. You can also easily reach us by phone to place an order.

Where Can Patients Purchase VitroCap®N?

In most countries, patients can conveniently order VitroCap®N from selected pharmacies or trusted online retailers. It is also available through the official distributor, ebiga-VISION, and their authorized partner shops. Simply click on your country flag to be redirected to the relevant shop page.