VitroCap®N: Comprehensive Information for Eye Care Professionals

VitroCap N package and capsules of the study testet micronutrient combination

Facts and Questions

Mechanism of Action

The vitreous body has a unique protective mechanism against oxidative stress and collagen glycation. However, this mechanism loses efficacy during degeneration. Providing the eye with naturally occurring micronutrients can help reactivate this mechanism, minimising or even preventing collagen fibres from clumping. The healthy vitreous exhibits notably high concentrations of micronutrients, including:

  • Vitamin C helps counter intraocular oxidative stress by consuming reactive oxygen species and free radicals in an ascorbate-dependent manner.
  • Zinc stimulates the synthesis of metallothionein, a metal-binding protein that protects tissues from glycoxidation, thus exhibiting antioxidative and antiglycation properties. Zinc is also an important cofactor of superoxide dismutase 3 (SOD3), a metalloprotein enzyme that catalyses the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Therefore, zinc also functions to regulate oxidative stress in the vitreous.
  • L-lysine, an essential free amino acid, helps prevent collagen glycation and serves as a chemical chaperone.
Schematic representation of the influence of micronutrients and zinc-containing enzymes (SOD) on collagen fibers in the vitreous body of the eye. On the left, a healthy eye with evenly distributed collagen fibers and high concentrations of vitamin C, free amino acids, zinc, and superoxide dismutase (SOD). On the right, an eye with clumped collagen fibers and lower concentrations of these micronutrients. The legend shows symbols for vitamin C (blue), free amino acids (green), zinc (grey), and SOD (orange). The illustration is based on the work of Ankamah, Nolan, and Huang.

Other micronutrients are known to effectively combat oxidative stress and protein glycation:

  • Proanthocyanidins found in grapes have been shown to inhibit protein glycation.
  • Hesperidin regulates oxidative stress and reduces the level of inflammatory cytokines by inhibiting the formation of advanced glycation end products, which in turn reduces the glycation of collagen.

Incorporating these micronutrients through supplementation with VitroCap®N may potentially slow down or even reverse, the progression of floaters. The effectiveness of this approach has been demonstrated in five clinical trials.

Did you know that eye care professionals can request free samples of VitroCap®N here?

Dosing and patient instructions

The recommended dosage is one capsule per day with a little liquid after a meal for an initial period of at least 3 to 6 months. Continuing use beyond this period should be tailored to your individual needs.

How to Objectively Prove the Reduction of Eye Floaters

In the Floater Intervention Study (FLIES), researchers used the ultra-widefield imaging module of the SPECTRALIS HRA + OCT from Heidelberg Engineering GmbH to capture a 30-second, 102° field, cross-polarised infrared reflectance video of the vitreous. Patients were asked to move their gaze in various directions, returning to a central fixation point after each movement. From the video, five still images of eye floaters were extracted, each from a different angle.

The vitreous opacity outlines were manually delineated using a ‘freehand selection‘ tool, and the areas of opacity were calculated for each image. These individual areas were then combined to provide a total measurement, reported in square centimetres.

Image data from the FLIES study showing vitreous opacities using ultra-widefield imaging (102° field of view) with cross-polarized infrared light, captured using the SPECTRALIS HRA + OCT system (Heidelberg Engineering). The top row displays five extracted still frames from a 30-second video of the vitreous body taken from different gaze directions, without markings. The bottom row shows the same images with manually outlined vitreous opacities in yellow. The area of each opacity was measured and documented in the table below. The goal was to objectively quantify the total opacity area from multiple angles.

Did you know?

The FLIES study is the first randomised, double-blind, placebo-controlled clinical trial to assess the impact of targeted nutritional supplementation on vitreous floaters. The trial included 61 patients aged 18-79 years. After 6 months of supplementation with VitroCap®N, 77% of patients experienced a reduction in vitreous opacity areas.

How to assess improvement of symptoms caused by vitreous opacities?

The assessment of symptoms caused by vitreous opacities is usually performed using subjective questionnaires. However, there is currently no uniform, standardized tool for classifying and quantifying the visual impairments caused by floaters.

To improve the diagnosis and monitoring of these symptoms, we are providing you with the validated questionnaire from the Floater Intervention Study (FLIES) for download. The placebo-controlled, double-blind FLIES study was conducted in 2021 at the Nutrition Research Centre Ireland (NRCI) – an independent, multidisciplinary research center specializing in studying the effects of nutrition and lifestyle on health.

As part of the study, participants completed the questionnaire before and after a six-month intake of VitroCap®N. The analysis showed that visual disturbances significantly improved in 67% of patients after six months of treatment with VitroCap®N.

The FLIES questionnaire enables a structured assessment of symptoms and can help reliably evaluate individual treatment success. You can download the questionnaire either as a fillable PDF for your patient records or as a print version for hard copies. Page two contains extended patient information. This makes the questionnaire suitable for early completion in the waiting room or for regular monitoring at home. 

Expert Opinions and Clinical Feedback

VitroCap®N has been on the market for over 10 years, with eye care professionals across Europe gathering valuable clinical experience. These experts have shared their insights, contributing to a broader understanding of the supplement’s impact. In discussions and contributions from both internationally and nationally renowned physicians and researchers, the latest findings on vitreous degeneration were explored, including its effects on visual function and quality of life.

Understanding FLIES: Prof. John Nolan on Groundbreaking Research

Prof. John Nolan is the founder of the Nutrition Research Centre Ireland (NRCI), a multidisciplinary team dedicated to studying the effects of nutrition and lifestyle on health and well-being. He is highly respected for his innovative clinical work and his commitment to improving quality of life through evidence-based scientific solutions. Watch his fascinating contribution to the symposium titled “Simply Transparent? The Vitreous in Focus” at the annual conference of the German Ophthalmological Society.

“Look at the Vitreous – Not Just Through It.” A satellite symposium dedicated to the vitreous body.

Update on vitreous structure, metabolism, nutrition, function and therapeutic options for vision-degrading myodesopsia with Dr. Jerry Sebag, Prof. John M. Nolan, Prof. Hans Hoerauf, Dr. Thomas Kaercher and Prof. Ulrich Welge-Lüßen. Watch the podium discussion in the embedded video; to follow each talk in full, please visit the symposium page, where all individual presentations are available.

Optometry Today Roundtable: "Can your patients benefit from vitreous management?"

Eye Floaters can be more than a mild nuisance—they often impact a patient’s day-to-day life. Yet discussing treatment options can be challenging. In an expert roundtable by Optometry Today in partnership with ebiga-VISION and VivaQuity, leading professionals shared their clinical experiences and approaches to managing floaters, offering fresh perspectives on this common condition.

VitroCap Reduces Eye Floaters In 70% Of Eyes!

A big thank you to Martin Oguzie from the YouTube channel “Martin the Optometrist” for this incredible, self-driven work. In his video, Martin takes a thoughtful deep dive into VitroCap®N as a solution for eye floaters. He goes above and beyond — thoroughly researching, reviewing multiple sources, and creating a clear, well-structured video enriched with his own clinical insights and outtakes from a symposium.

For full transparency: Martin is not affiliated with VitroCap®N, ebiga-VISION, or VivaQuity in any commercial way. As he himself puts it: “It’s important to me to remain unbiased — because the floater community expects and deserves that.”

Complete Study Data on VitroCap®N

Research Team
Year
Duration
Design
Success Rate
Link
Ankahmah et al
2021
6 months
RCT (double-blind)
66.7%
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525826/
Varganova et al.
2019
3 months
Case-control study
76%
https://journals.eco-vector.com/ov/article/view/11875
Sobol et al.
2018
3 months
Observational study
64.7%
https://www.researchgate.net/publication/326345092
Marchencko et al.
2015
3 months
Case-control study
65.5%
https://ebiga-vision.com/marchencko-et-al.pdf
Kaercher et al.
2013
3 months
Observational study
87.5%
https://ebiga-vision.com/ZPA_9-2023-eye-floater-symposium

Why the SUPPLEMENT CERTIFIED Seal Matters

Logo Supplement Certified

VitroCap®N  has been awarded the SUPPLEMENT CERTIFIED seal – an independent, science-backed certification confirming product activity and stability in accordance with label claims.

Our quality standards go well beyond the legal requirements for dietary supplements. Through continuous quality control, strict validation processes, and recognized certifications, we ensure that eye care professionals can confidently recommend safe and reliable micronutrient formulations.

Supplement Certified represents the highest level of verification: an independent, science-supported, and ISO-accredited mark of credibility and quality.

“If you find a supplement with the Supplement Certified logo, it means that that product lot has been tested by us, and provides 100 % of its active ingredient label claim. This also means that the company is committed to quality and continued testing of their product over time.” www.supplementcertified.ie

Request Free Samples and Informational Material

ebiga-VISION aims to give medical professionals the opportunity to assess the product, provide their patients with comprehensive and straightforward advice, and offer them an evidence-based option for the management of floaters.

Patent – A Milestone for Vitreous Floater Research and Patient Protection

The granting of a European patent for the micronutrient formulation of VitroCap®N marks a major milestone – not only for our company, but also for the many people across Europe affected by vitreous floaters and the healthcare professionals who support them. On the one hand, the patent officially confirms that VitroCap®N represents a true innovation. On the other, it protects a product that offers a scientifically grounded and effective treatment option in a field that has long lacked adequate therapeutic solutions.

Read our patent statement here

How to Stock VitroCap®N for Resale

Please contact us using our contact form. We would be happy to send you a PDF with our current prices and discount levels for practice shop owners. You can also easily reach us by phone to place an order.

An eye examination in progress: A male patient is seated at a slit lamp while a female optometrist or ophthalmologist performs the test, focusing on his eye health.

Where Can Patients Purchase VitroCap®N?

In most countries, patients can conveniently order VitroCap®N from selected pharmacies or trusted online retailers. It is also available through the official distributor, ebiga-VISION, and their authorized partner shops. Simply click on your country flag to be redirected to the relevant shop page.

Disclaimer

This content is intended solely for the eyes of healthcare professionals. Please confirm below: