Diagram of the eye showing normal versus clumped collagen fibers in the vitreous. Left: normal eye with evenly distributed collagen fibers, supported by Vitamin C, free amino acids, zinc, and superoxide dismutase. Right: eye with clumped collagen fibers appearing as floaters. Legend explains symbols: Vit.C = Vitamin C, FAA = free amino acids, Zn = zinc, SOD = superoxide dismutase 3.

Floater treatment: Non-invasive innovation with placebo-controlled proof of efficacy

Since 2013, substantial scientific research has evaluated the effectiveness of micronutrient supplementation in managing eye floaters. 

The most recent Floater Intervention Study (FLIES) stands out as particularly significant. Not only did it show improvements in subjective visual disturbance scores and improved visual function, but researchers also utilized the ultra-widefield imaging module of the SPECTRALIS HRA + OCT from Heidelberg Engineering GmbH to capture a 30-second, 102° field, cross-polarized infrared reflectance video of the vitreous. From this video, five still images of eye floaters were extracted, making the areas of vitreous opacities visible. After 6 months, objective improvement of eye floaters was proven in 77% of patients.

Explore this page to discover everything about the tested micronutrient VitroCap®N—its mechanism of action, clinical feedback, and instructions for ordering samples or stocking it in practice shops, and more.

FLIES Floater Intervention Study

After 6 months, objective improvement of eye floaters was proven in 77% of patients. Fill out the form to receive the complete study data via email.

Understanding VitroCap®N: The Evidence-Based Micronutrient Complex

VitroCap N package and capsules of the study testet micronutrient combination

Table of content

Mechanism of action

The vitreous body has a unique protective mechanism against oxidative stress and collagen glycation. However, this mechanism loses efficacy during degeneration. Providing the eye with naturally occurring micronutrients can help reactivate this mechanism, minimising or even preventing collagen fibres from clumping. The healthy vitreous exhibits notably high concentrations of micronutrients, including:

  • Vitamin C helps counter intraocular oxidative stress by consuming reactive oxygen species and free radicals in an ascorbate-dependent manner.
  • Zinc stimulates the synthesis of metallothionein, a metal-binding protein that protects tissues from glycoxidation, thus exhibiting antioxidative and antiglycation properties. Zinc is also an important cofactor of superoxide dismutase 3 (SOD3), a metalloprotein enzyme that catalyses the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Therefore, zinc also functions to regulate oxidative stress in the vitreous.
  • L-lysine, an essential free amino acid, helps prevent collagen glycation and serves as a chemical chaperone.

Other micronutrients are known to effectively combat oxidative stress and protein glycation:

  • Proanthocyanidins found in grapes have been shown to inhibit protein glycation.
  • Hesperidin regulates oxidative stress and reduces the level of inflammatory cytokines by inhibiting the formation of advanced glycation end products, which in turn reduces the glycation of collagen.

Incorporating these micronutrients through supplementation with VitroCap®N may potentially slow down or even reverse, the progression of floaters. The effectiveness of this approach has been demonstrated in five clinical trials.

Did you know that eye care professionals can request free samples of VitroCap®N here?

Ingredients

Nutritional information
Per capsule = Recommended daily intake
Percentage of reference intake per capsule*
Zinc
5 mg
50%
Vitamin C
40 mg
50%
Grape seed extract
26,3 mg
**
– of which proanthocyanidins
25 mg
**
Citrus fruit extract
100 mg
**
– of which citrus flavonoids (hesperidin)
60 mg
**
L-Lysine
125 mg
**

* Percentage of the reference intake per EU Regulation 1169/2011
** no nutrient reference values available / no recommendation available in the EU

Gluten-free, lactose-free, made in Europe

Dosing and patient instructions

The recommended dosage is one capsule per day with a little liquid after a meal for an initial period of at least 3 to 6 months. Continuing use beyond this period should be tailored to your individual needs.

How to objectively prove the reduction of eye floaters

In the Floater Intervention Study (FLIES), researchers used the ultra-widefield imaging module of the SPECTRALIS HRA + OCT from Heidelberg Engineering GmbH to capture a 30-second, 102° field, cross-polarised infrared reflectance video of the vitreous. Patients were asked to move their gaze in various directions, returning to a central fixation point after each movement. From the video, five still images of eye floaters were extracted, each from a different angle.

The vitreous opacity outlines were manually delineated using a ‘freehand selection‘ tool, and the areas of opacity were calculated for each image. These individual areas were then combined to provide a total measurement, reported in square centimetres.

Two fundus images of an eye in comparison: left image before and right image after 6 months of VitroCap® N intake. The yellow outline marks vitreous opacities. After supplementation, a clear reduction in the opacity area is visible, indicating a decrease in vitreous floaters. The image illustrates a potential structural improvement associated with the use of VitroCap® N.

Did you know?

The FLIES study is the first randomised, double-blind, placebo-controlled clinical trial to assess the impact of targeted nutritional supplementation on vitreous floaters. The trial included 61 patients aged 18-79 years. After 6 months of supplementation with VitroCap®N, 77% of patients experienced a reduction in vitreous opacity areas.

How to assess improvement of symptoms caused by vitreous opacities?

The assessment of symptoms caused by vitreous opacities is usually performed using subjective questionnaires. However, there is currently no uniform, standardized tool for classifying and quantifying the visual impairments caused by floaters.

To improve the diagnosis and monitoring of these symptoms, we are providing you with the validated questionnaire from the Floater Intervention Study (FLIES) for download. The placebo-controlled, double-blind FLIES study was conducted in 2021 at the Nutrition Research Centre Ireland (NRCI) – an independent, multidisciplinary research center specializing in studying the effects of nutrition and lifestyle on health.

As part of the study, participants completed the questionnaire before and after a six-month intake of VitroCap®N. The analysis showed that visual disturbances significantly improved in 67% of patients after six months of treatment with VitroCap®N.

The FLIES questionnaire enables a structured assessment of symptoms and can help reliably evaluate individual treatment success. You can download the questionnaire either as a fillable PDF for your patient records or as a print version for hard copies. Page two contains extended patient information. This makes the questionnaire suitable for early completion in the waiting room or for regular monitoring at home. 

Expert opinions and clinical feedback

VitroCap®N has been on the market for over 10 years, with eye care professionals across Europe gathering valuable clinical experience. These experts have shared their insights, contributing to a broader understanding of the supplement’s impact. In discussions and contributions from both internationally and nationally renowned physicians and researchers, the latest findings on vitreous degeneration were explored, including its effects on visual function and quality of life.

Optometry Today Roundtable: "Can your patients benefit from vitreous management?"

See the full discussion on YouTube.

  • Dr. Frank Eperjesi
  • Dr. Scott Mackie
  • Dr. Thomas Kaercher
  • Prof. John M. Nolan 

Satellite symposium: “Look at vitreous- not just through it.”

The videos from the symposium can be found here. 

  • Dr. Jerry Sebag
  • Prof. John M. Nolan
  • Prof. Hans Hoerauf
  • Dr. Thomas Kaercher
  • Prof. Ulrich Welge-Lüßen

VitroCap Reduces Eye Floaters In 70% Of Eyes!

A big thank you to Martin Oguzie from the YouTube channel “Martin the Optometrist” for this incredible, self-driven work. In his video, Martin takes a thoughtful deep dive into VitroCap®N as a solution for eye floaters. He goes above and beyond — thoroughly researching, reviewing multiple sources, and creating a clear, well-structured video enriched with his own clinical insights and outtakes from a symposium.

For full transparency: Martin is not affiliated with VitroCap®N, ebiga-VISION, or VivaQuity in any commercial way. As he himself puts it: “It’s important to me to remain unbiased — because the floater community expects and deserves that.”

Complete study data on VitroCap®N

Research Team
Year
Duration
Design
Success Rate
Link
Ankahmah et al
2021
6 months
RCT (double-blind)
66.7%
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525826/
Varganova et al.
2019
3 months
Case-control study
76%
https://journals.eco-vector.com/ov/article/view/11875
Sobol et al.
2018
3 months
Observational study
64.7%
https://www.researchgate.net/publication/326345092
Marchencko et al.
2015
3 months
Case-control study
65.5%
https://ebiga-vision.com/marchencko-et-al.pdf
Kaercher et al.
2013
3 months
Observational study
87.5%
https://ebiga-vision.com/ZPA_9-2023-eye-floater-symposium

Request free samples and informationalmMaterial

ebiga-VISION aims to give you the opportunity to assess the product yourself, provide your patients with comprehensive and straightforward advice, and offer them an evidence-based option for the management of floaters.

How to stock VitroCap®N for resale

Please contact us using our contact form. We would be happy to send you a PDF with our current prices and discount levels for practice shop owners. You can also easily reach us by phone to place an order.

An eye examination in progress: A male patient is seated at a slit lamp while a female optometrist or ophthalmologist performs the test, focusing on his eye health.

Where can patients purchase VitroCap®N?

In most countries, patients can conveniently order VitroCap®N from selected pharmacies or trusted online retailers. It is also available through the official distributor, ebiga-VISION, and their authorized partner shops. Simply click on your country flag to be redirected to the relevant shop page.

Contact the distributor

Leave a brief message and a member of ebiga-VISION will contact you as soon as possible